الفهرس 
Chapter I: Acne VulgarisOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris is a multifactorial chronic inflammatory disorder
of the pilosebaceous follicles of human skin (54). Interleukin 19 is a
member of the IL-10 family of cytokines which includes IL-10, IL-19,
IL-20, IL-22, IL-24 and IL-26 (84).
The present research was intended to evaluate the interleukin-19
serum levels and gene polymorphism in acne vulgaris patients and
their correlation to disease severity.
This case control study was conducted on total number 90
patients with different clinical varity of acne vulgaris and 90 age and
sex matched healthy subjects as control group.
The result of the current study showed that: Interlukin-19 serum
levels showed statistically significant higher mean values in acne
vulgaris patients than the control group (122.1±115.9 pg/ml vs.
32.2±22.3pg/ml) (p = 0.001). Also, there was significant association
between serum level of IL 19 and severity of acne vulgaris. Studying
the relation between IL-19 serum levels and studied sociodemographic
and clinical criteria of acne patients revealed nonsignificant
correlations or associations except for onset of AV disease
(P=0.036).
Regarding IL-19 C/T polymorphism, TT genotype was
significantly higher in AV cases (41, 45.6 %) than in controls ( 13,
14.4%) with 13.6 OR, as well CT genotype was observed in cases
than controls with 6.4 OR (P = 0.001). Additionally, IL-19 T allele
was significantly reported in acne vulgaris cases than controls (66.1%
vs.28.3%) (P = 0.001).
Summary
70
Studying the relation between IL-19 C/T genotypes with sociodemographic
and clinical data of acne patients, there was statistical
significant difference between different IL 19 genotype and
progressive course, duration of disease and type of acne (P < 0.05).
However, there was non-statistical significant difference between
different IL 19 genotype with age, gender, onset and family history of
the disease (P>0.05).
Relationship between IL 19 genotype and serum level, IL 19
serum level was significantly higher in patients with genotype TT than
in those with genotype CC (P2 = 0.002), also IL 19 serum level in
patients with genotype CT than in those with genotype CC (p3 =
0.001). However there was non-statistical significant difference
between patients with genotype TT and CT regarding IL 19 serum
level (p1 = 0.085).