الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Chronic kidney disease (CKD) is becoming a common disease
in the general population and is associated with an increased risk of
mortality.
Registry studies indicated that cardiovascular disease (CVD) is,
accounting for nearly 50% of deaths in dialysis patients.
Recent studies examining cardiovascular complications in
dialysis patients focused on atherosclerosis.
Magnesium is the second most abundant intracellular cation and
it plays a key role in a wide range of cellular functions
In recent studies, low serum magnesium has been associated
with inflammation and disturbances in the regulation of vascular tone
and endothelial function which contribute to the development and
progression of atherosclerosis.
We aimed to study the correlation between the level of serum
magnesium and atherosclerotic changes as well as CIMT.
This cross-sectional study evaluated 60 HD patients in the
dialysis unit of Menouf general hospital, Menuofia governorate, Egypt
during the period from May 2017 to May 2018.
Patients were classified into 3 groups: after elimination of
exclusion criteria
group I:
Included 20 patients with ESRD on regular hemodialysis with
normal serum magnesium levels (1.7 -2.8mg/dl).
Summary
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group II:
Included 20 patients with ESRD on regular hemodialysis with
low serum magnesium levels less than 1.7mg/dl.
group III:
Included 20 patients with ESRD on regular hemodialysis with a
high serum magnesium level of more than 2.8mg/dl.
Doppler ultrasound for carotid arteries used To assess CIMT by
a real-time high-resolution B-mode ultrasonography.
Echocardiography is used to assess IHD in patients.
Patient basic clinical and biochemical data were recorded.
Serum magnesium and Lipid profile were measured before HD
sessions.
Results of the current study could be summarized as follow:
There was no significant difference between the three groups in
the study as regards Gender, DM, HTN, and smoking. The
difference between the three groups was highly significant as
regards IHD in hypomagnesemia.
There was no significant difference between the three groups in
the study as regards age and Duration of hemodialysis.
The difference between the three groups was statistically
significant as regards Dry weight. Dry weight higher in group III
Hyper-magnesemia and the difference between the three
groups was statistically significant as regards BMI. BMI was
lower in group Ⅱ (Hypo-magnesemia).
Summary
83
The difference between the three groups was highly significant
as regards cholesterol and LDL levels which were higher in group
II (hypo-magnesemia.
There was a significant statistical difference between the 3
groups as regards the level of Triglycerides which was higher in
group II (hypo-magnesemia).
There was a significant statistical difference between the 3
groups as regards the level of HDL which was higher in groupIII
(Hyper- magnesemia).
There was a statistical significant difference between the 3
groups as regards CCA-IMT which was higher in group II(Hypomagnesemia)
There was no statistically significant difference between the 3
groups as regards levels of serum sodium, serum potassium,
serum calcium, serum phosphate, and level of parathyroid
hormone.
A non-significant association between the level of serum Mg
and Gender, DM, HTN, and smoking.
a significant association between serum Mg and IHD
A non-significant association between CCA-IMT and Gender,
HTN, and smoking.
A significant association between CCA-IMT and DM.
A non-significant association between level of serum Mg and
age, duration of dialysis, Triglycerides, level of serum Ca, level of
serum phosphate, and parathyroid hormone.
Summary
84
A high significant negative association between the level of
serum Mg and cholesterol level.
A high significant negative association between the level of
serum Mg and cholesterol level.
A high significant negative association between serum Mg
and LDL level in the studied groups.
A significant negative association between serum Mg and
CCA- IMT in the studied groups.
A significant negative association between serum Mg and IHD
in the studied groups.
Non-significant association between CCA-IMT and BMI,
duration of dialysis, HDL, LDL, level of serum Ca, phosphate,
and parathyroid hormone.
a significant positive association between CCA-IMT and age in
the studied groups.
A significant positive association between CCA-IMT and
cholesterol in the studied groups.
A significant positive association between CCA-IMT and
Triglycerides in the studied groups.
A non-significant association between IHD and BMI, duration
of dialysis, cholesterol, Triglycerides, HDL, level of serum Ca,
level of serum phosphate, and parathyroid hormone.
A significant positive association between IHD and age.
A significant positive association between IHD and LDL.
Summary
85
Regarding linear regression showed that Age, Cholesterol,
Triglycerides, and DM are Predictors for CIMT While serum
Magnesium is not a predictor for CIMT.
Regarding binary logistic regression showed that Age and
Triglycerides are Predictors for IHD While serum Magnesium,
Cholesterol, and LDL are not a predictor for IHD.
Limitations of our study were as follows:
Our study has two main limitations; the small sample size and
its observational nature. Therefore, further prospective, randomized,
controlled studies are needed to determine the possible beneficial
effects of supplementing this element on carotid artery atherosclerosis
in HD patients.