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Abstract Approximately 10% of world population has been affected by chronic kidney disease (CKD), and nearly 3 million people worldwide currently have been taking renal replacement therapy mostly in the form of hemodialysis. Hemodialysis is a complex process that requires regular dialysis center visits and affects the patient life style in all aspects. When we think of the quality of life in the aspect of health and disease, we can use the term health-related quality of life (HRQOL). HRQOL is a combination of several components due to multi dimensional nature of health including physical, social, emotional, and mental. Vitamin D deficiency is common in CKD and maintenance hemodialysis patients Low bone mineral density, muscle weakness, metabolic syndrome, vascular calcification and stiffness, progression of kidney disease, left ventricular hypertrophy, atherosclerosis and infection are several conditions that can be associated with vitamin D deficiency in CKD and hemodialysis patients, and all of these conditions can indirectly or directly affect the quality of life. Aim of the work The aim of our study was to investigate the relationship between vitamin D levels and HRQOL in maintenance hemodialysis patients and provide useful information on such an important issue. Patients and methods The present study involved 85 end-stage renal disease (ESRD) patients treated with conventional maintenance hemodialysi |