الفهرس 
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Abstract
Acute myocardial infarction (AMI) is one of the main etiologies of death globally. It was demonstrated to be associated with irreversible damage to the heart muscle due to a lack of oxygen with a subsequent impairment in diastolic and systolic function and makes the patient prone to arrhythmias. In AMI, platelets were demonstrated to play a main role in thrombotic processes that limit the patency of the recanalized, infarct-related coronary artery and contribute to reperfusion injury. Platelet volume is an important indicator for platelet function and activation. Thus, the aim of the present study was to evaluate MPV as an early and independent predictor for AMI in patients with acute chest pain. This was a retrospective observational analytical study carried out on a total of 107 patients presenting with acute chest pain. Of which, 36 cases were diagnosed as stable coronary artery disease and 71 cases were diagnosed as AMI presenting to Mansoura Emergency Hospital within the period from January 2019 to January 2020. This study revealed the following results: * There were statistically significant differences among both groups regarding age, female sex and BMI being increased in AMI groups (P<0.05). * Hypertension, DM and dyslipidemia were significantly increased among AMI cases compared to stable coronary artery disease ones (P<0.05). * Family history of CAD, prior MI, prior PCI, drug history (β-blocker and Dual anti-platelet) and death were demonstrated to be significantly increased among AMI cases compared to stable coronary artery disease ones. * Stable coronary artery disease cases demonstrated significant increase in platelet count and significant decrease in MPV compared to AMI ones (P<0.05). * MPV could be used as a reliable predictor in terms of the differentiation between AMI from stable coronary artery disease cases with higher sensitivity, specificity and accuracy. * AMI cases were demonstrated to be significantly associated with advanced age as well as higher BMI (P<0.05). * DM, dyslipidemia, smoking, family history of CAD, prior MI and prior PCI were demonstrated to be significantly increased among AMI cases. * There was a statistically significant correlation among MPV and stenosis among AMI cases (P<0.05). * MPV could be used as a reliable predict for death among AMI cases with high sensitivity and accuracy with moderate specificity. * Hypertension, DM, dyslipidemia, family history of CAD, prior MI, prior PCI and MPV could be used as significant predictors for AMI (P<0.05).