الفهرس 
صفحة العنوانOnly 14 pages are availabe for public view
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Abstract
Carbon nanomaterials (CNMs) include graphene quantum dots (GQDs), graphene oxide nanosheets (GO), single and multiwalled carbon nanotubes (SWCNTs, MWCNTs) exhibit different loading capacities, release rates, and targeting abilities. This explains the reported discrepancy of their associated therapeutic efficiencies when used as drug carrier systems. In this study, In this study, for the first time, different types of CNMs were synthesized. fully characterized. loaded with the chemotherapeutic Doxorubicin (DOX) and compared under the same conditions. The effect of shape (spheres, tubes and sheets), size (30 -180 nm), and surface charge (-64.9 to -11.85 mv) of the synthesized CNMs on DOX loading and release efficiency as well as .~ cytotoxicity against MCF-7 cells was investigated. Furthermore, the biosafety of the synthesized GQDs was studied both at the in vitro level using human WI-38 cells and at the in vivo level at low and high dose of 5 and 20 mg/Kg using healthy female Wister rats. GO nanosheets showed the highest DOX loading capacity, 2.85mg/mg. GQDs2 exhibited the highest release rate, 78.1 %. The in vitro cytotoxicity evaluation indicated that the smallest spherical nanomaterial among the broad family of CNMs, namely GQDs (type 1 ) was the most efficient one in delivering DOX into the cells and inhibiting their proliferation. Regarding the biosafety, all CNMs displayed no noticeable cytotoxicity against Wl-38. Moreover, hematological, biochemical and histological assessment of both kidneys and livers of treated rats assured the high biosafety level. We also present new insights on the first principle calculations investigating the adsorption of DOX on graphene and GO. The calculations showed that DOX molecules adsorb almost equally on graphene and GO. However, the flaky nature of our GO mono layers allows for sandwich-like structures to exist. enhancing its loading capacity over GQDs