الفهرس 
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Abstract
Background: Nephrotic syndrome is one of the most important kidney
diseases in paediatric age group. It cause leakage of several proteins in
urine such as certain coagulation factors and antithrombin III.
Objective: To predict the possible risk of thromboembolic complication
development in children with nephrotic syndrome due to antithrombin III
deficiency and to compare between serum levels of antithrombin III in
patients with nephrotic syndrome during both relapsing and after 6
weeks of the start of steroid treatment.
Patients and Methods: This study was cross sectional study
conducted in outpatient Nephrology Clinic of Children’s Hospital,
Fayoum University started from January 2016 to December 2016. It
included 27 children with nephrotic syndrome to be followed during both
relapse and after 6 weeks after start of steroid therapy, and 27 healthy
children as control group.
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Results: There were significant decreases in antithrombin III, albumin
and total proteins levels in the study group during relapse but after steroid
therapy their levels were improved while there were significant increases
in platelet count, cholesterol, triglycerides levels during relapse which
also improved after steroid therapy. There was no thromboembolic
complications detected among the study group.
Conclusions: antithrombin III level was significantly decrease in
children with nephrotic syndrome and despite of the hypercoagulable
state no thromboembolic complications can be detected in children with
nephrotic syndrome.
Keywords: Nephrotic syndrome - Antithrombin III - Steroid therapy -
Hypercoagulable state - Thromboembolic complications.