الفهرس 
Bronchopulmonary dysplasiaOnly 14 pages are availabe for public view
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Abstract
Most preterm babies require supplemental oxygen for a variable period of time. The current routine monitoring relies on oxygen saturation by pulse oximetry without identifying the underlying pathology.
Very low birth weight infants who remain on mechanical ventilation after 1 to 2 weeks of age are at very high risk of developing BPD.
When considering corticosteroid therapy for such an infant, clinicians might conclude that the risks of a short course of glucocorticoid therapy to prevent BPD are warranted. The aim of the study was to describe the use of the integrated assessment of respiratory physiology using Targeted Neonatal Echocardiography, and the tolerance of lung oxygen uptake at different oxygen levels, and hence early prediction of Bronchopulmonary Dysplasia and the underlying pathophysiology Methods:
A prospective study conducted in the NICU of Maadi, and Ghamra military hospitals, from 2016- 2018 to daily evaluate oxygen histograms with measurement of the cumulative time of oxygen saturations below 80%, and arterial oxygen saturations SaO2 above 95% in 30 preterm infants on oxygen support with weekly evaluation of oxygen tolerance test (OTT).
Results:
We found that, the use of integrated approach led to significant reduction of oxygen and hospital days. There was clinically and statistically significant reduction in these days after implementation of the approach, as well as sepsis percentage. Comparing oxygen days of the two groups before and after the application of the integrated approach (treatment algorithm), there was significant decrease in oxygen days from mean 14 to mean 6. While hospital days decreased from mean 26 to mean 9, and sepsis decreased from 88% to 24%.
Oxygen tolerance test in preterm infants predicts and indentifies BPD. P value was <0.05 that rejects null hypothesis, indicating that overall predictability of oxygen tolerance test is significant.
We have a mechanism to identify BPD. Therefore, the use of corticosteroids for the prevention of BPD should be done after application of this integrative approach.
Conclusions:
Integrated approach helped to reduce oxygen and hospital days as well as sepsis incidence.
There was a statistical correlation between death before discharge and oxygen tolerance test, and proves that oxygen tolerance test in preterm infants predicts and identifies BPD