الفهرس 
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Abstract
Objective: The current study was designed to determine the protective and curative effects of thymoquinone or vitamin C on some hematological and biochemical parameters in gentamicin-induced nephrotoxicity in adult male albino rats.
Methods:
Seventy male albino rats were used in the current work. Rats were divided into 6 groups; 1st group: normal control, 2nd group: thymoquinone (TQ), 3rd group: vitamin c (vit. C), 4th group: gentamicin (G), 5th group: thymoquinone + gentamicin (TQ+G) and 6th group: vitamin C + gentamicin (Vit. C+ G). Nepheotoxicity was induced in adult male albino rats by injection of gentamicin at a dose 100 mg/kg b.wt. intraprotenially for 5 days.
Results: Intraperitoneal injection of gentamicin led to a significant elevation in the levels of urea, creatinine, uric acid, malondialdehyde (MDA), total nitric oxide (TNO) level and inflammatory cytokines (TNF-α & IL-1β) levels. Meanwhile, gentamicin treatment exerted a significant decrease in the levels of total protein, albumin, red blood cells (RBCs) count, haemoglobin (Hb) concentration, haematocrit (Hct) level, white blood cells (WBCs) and platelets count as compared to their corresponding normal control group. After nephrotoxic rats treated with thymoquinone or vitamin C for 15 and 30 days, a remarkable correction was occurred in all previous parameters dependent on time of treatment.
Conclusion: Administration of thymoquinone or vitamin C pre-gentamicin led to decrease the disturbance occurred in kidney tissue in rats.