الفهرس 
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Abstract
Background: Neuromyelitis Optica (NMO) previously known as Devic’s syndrome is an autoimmune, inflammatory and demyelinating disorder of the central nervous system with predominant affection of the optic nerves and spinal cord. The global incidence and prevalence of NMO is incompletely characterized. To be more specific, it is unclear whether disease severity, frequency, clinical picture, and gender predominance vary between geographical regions. It’s really challenging to obtain epidemiological and demographic data for a disorder like NMO, as it’s relatively uncommon.
Aim of the Work: Study the demographic data of the patients affected with NMOSD attending ASU neurology MS unit, Document patient’s response to treatment. and to estimate the incidence rate of NMOSD, according to the new international consensus NMO Diagnosis criteria.
Patients and Methods:
Patient attending ASU MS unit, during one year study time, Age: 18 to 65 years old, with Diagnosis of NMODS according to the International consensus on NMODS.
Results: 50 NMO patients were enrolled in this study, Mean age of NMO patients was 33.140 ± 9.136, ranging from 20 to 59 years, 39 were females representing 78% of the study group while 11 were males representing 22%. EDSS showed significant relation with treatment during acute attack and receiving DMD as a preventive therapy with p-value 0.052 and 0.024 respectively.
Conclusion: Since the landmark discovery of AQP4-IgG, the clinical spectrum of NMO has expanded, and non- optico-spinal clinical manifestations are recognized, accordingly rational targeted treatments have been identified that are now being delivered to patient care.