الفهرس 
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Abstract
This study was carried out on 45 pregnant females aged 20 - 40 years (y) admitted to El-Shatby University Hospital. All patients were of American Society of Anaesthesiologist (ASA) physical status I or II, scheduled for elective caesarean section under spinal anaesthesia. After taking approval of the ethical committee, and a written informed consent from every patient involved in the study, parturients in the study were randomly categorized into 3 equal groups by the closed envelope technique.
Patients were randomly divided into three equal groups (15 patients each):
group I: Patients received ondansetron 4 milligrams (mg) intravenous (IV) 5 minutes before intrathecal block.
group II: Patients received granisetron 1 milligram (mg) intravenous (IV) 5 minutes before intrathecal block.
group III: Patients received 10 ml normal saline 5 minutes before spinal block.
The results of the present study showed that:
1- Demographic data
Age, Weight, Height, body mass index, gestational age, number of previous caesarean sections, time of delivery and Duration of Surgery:
The mean age for the three studied groups was 28.80±6.14, 29.0± 6.63, 29.33±5.78 respectively.
The mean weight for the three studied groups was 71.60±6.10, 68.80±5.91 and 70.80±6.03 respectively.
The mean height for the three studied groups was 164.33±7.53, 168.47±8.27 and 165.67±8.30 respectively.
The mean body mass index (BMI) for the three studied groups was 26.60±2.64 ,24.33±2.46 and 25.91±2.74 respectively.
The mean gestational age for the three studied groups was 39.33±0.72, 38.93 ±0.88 and 0.70 respectively.
The mean number of previous caesarean sections in the three studied groups was 1.87±1.30, 1.93±1.10 and 1.80±1.01 respectively.
The mean time of delivery for the three studied groups was 7.40±2.75, 7.73±1.94 and 7.33±1.95 respectively.
The mean duration of surgery for the three studied groups was 31.67 ±3.54, 30.93± 3.94 and 31.53±4.05 respectively.
Regarding age, weight, height, body mass index, gestational age, number of previous caesarean delivery, time of delivery and duration of surgery; there were no statistical significant differences between the three studied groups.
2- Haemodynamic parameters:
a- Systolic arterial blood pressure (SAP) changes:
Comparison between the three studied groups reveled no significant differences at base line value, before SA, immediately after SA, 14 min, 16 min or 18 min. (p= 0.489, 0.720, 0.222, 0.192, 0.537 respectively). A significant decrease was detected at all other times of measurements at 2, 4, 6, 8, 10, 12, 23, 28, 33, 38, 43 minutes (p= 0.025, 0.040, 0.001, <0.001, 0.001, 0.013, <0.001, 0.001, <0.001, 0.001, 0.006).
Between group I and II, there was a significant decrease at 2, 4, 6, 8, 23, 28, 33, 38, 43 minutes (p1= 0.022, 0.031, 0.006, <0.001, 0.034, 0.001, <0.001, 0.001, 0.005 respectively). Decrease in SAP in group II < group I. Between group I and III, there was significant decrease at 10, 12, 23, 33, 38 minutes (p2= 0.003, 0.015, 0.022, 0.009, 0.024 respectively), decrease in SAP in group I group III.
Between group II and III, there was significant decrease at 6, 8, 10, 12, 23, 28
minutes (p= 0.002, <0.001, 0.001, 0.027, <0.001, 0.008 respectively). Decrease in
SAP in group in group III