الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Lanthanide Complexes as Photo Probes for the Assessment of some
drugs in different body fluids.
The present thesis comprises of four main chapters:
The first chapter
Introduction and literature review, this chapter is concerned with focusing
light on the chemistry of Lanthanide metal ions through their Luminescent
properties, their sensitization Process and their chromophore excitation especially
Complexes of Eu3+ and Tb3+ which show strong luminescence in the visible
region and have been widely exploited in various applications especially
fluoroimmuno assays and structural probes.
The first chapter also includes the chemistry, structural, properties and the
analytical methods used for detection of two central nervous system drugs such
as (oxcarbazepine and Sulpiride) and lipids lowering agents such as
(Atorvastatin, Ezetimibe and Simvastatin ) in addition to an anti- viral drug
(Acyclovir) .
The second chapter describes a selective and sensitive spectrofluorometric
method for the assessment of two central nervous system drugs (Oxcarbazepine
and Sulpiride) in serum samples based on the enhancement of luminescence
intensity of the photo probe Eu3+. it was found that there is enhancement of
fluorescence intensity between photo probe and the two drugs under study in
addition to the measurement of photo probe emission and excitation wavelength
(λex=390) nm under different conditions of solvent. The optimum conditions for
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measurement are DMSO as solvent. The photo probe has been used for different
concentrations of drugs at wavelength of emission (λem=618) nm illustrates the
experimental work concerning the methods of preparation and
standardization of solutions, it also includes the instruments used in the
different measurements and methods of calculations.
The third chapter is concerned with three lipid lowering agents
(Atorvastatin, Ezetimibe and Simvastatin) describes a selective and sensitive
spectrofluorometric method for the assessment of the three lipids lowering agents
in serum samples based on the enhancement of luminescence intensity of the
photo probe Eu3+. it was found that there is enhancement of fluorescence
intensity between photo probe and the two drugs under study in addition to the
measurement of photo probe emission and excitation wavelength ( λex=340) nm
under different conditions of solvent. The optimum conditions for measurement
are DMSO as solvent. The photo probe has been used for different concentrations
of drugs at wavelength of emission (λem=545) nm illustrates the experimental
work concerning the methods of preparation and standardization of
solutions, it also includes the instruments used in the different measurements and
methods of calculations.
In Chapter four the anti-viral drug, Acyclovir tablet was examined by using the
photo probe Tb3+ hence, it describes a selective and sensitive spectrofluorometric
method for the assessment of the in serum samples based on the enhancement of
luminescence intensity of the photo probe Eu3+. it was found that there is
enhancement of fluorescence intensity between photo probe and the drug under
study, the measurement of photo probe emission and excitation wavelength
(λex=340) nm under different conditions of solvent. The optimum conditions for
130
measurement are DMSO as solvent. The photo probe has been used for different
concentrations of drugs at wavelength of emission (λem=545) nm illustrates the
experimental work concerning the methods of preparation and standardization of
solutions, it also includes the instruments used in the different measurements and
methods of calculations.