الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Adropin is a newly discovered endogenous bioactive substance that is mainly expressed in the heart, brain, liver and coronary endothelial cells. Adropin is involved in regulating lipid metabolism, improving insulin resistance, protecting vascular endothelial cells, and anti-inflammatory effects.
Adropin can increase the endothelial nitric oxide synthase expression, which has a certain endothelial cell protection potential. We investigate the correlation of adropin and ischaemic heart disease in diabetic patients.
Aim of study is assessment of serum adropin level as a risk factor for ischaemic heart disease in type 2 diabetes mellitus cases.
Patients of both gender (male and female) were included Patients aged from 35-65 years old.
Patients candidates were divided into three groups.
First group is 30 diabetics type 2 with ischaemic heart disease
Second group is 30 diabetics type 2 without ischaemic heart disease
Third group is 30 control healthy group.
All candidates are subjected to full history taking , physical examination including height, weight, BMI and blood pressure measurement. Laboratory investigations including FBS and Post prandial glucose tests HbA1c HOMA IR lipid profile Liver function test Kidney function test CBC and cardiac enzymes
Subclinical atherosclerosis (SA), described as having a carotid artery intima-media thickness (CIMT) of ≥ 0.9 mm and/or a plaque on the common carotid artery, without clinical manifestations, has been closely associated with hyperlipidemia. therefore, using CIMT to predict the progression and regression of atherosclerosis has become widely accepted in clinical prac¬tice.
According to our study , we found that adropin level was significantly decreased in T2DM patients compared with control subjects.
Also according to our study we found adropin level was statistically significantly higher in group 2 (diabetic group without ischaemic heart disease) than group 1 (diabetics with ischaemic heart disease) with p value <0.001, with raised adropin levels within diabetics without IHD.
Also in our study we found a highly significant negative correlation between insulin and adropin of T2DM patients p <0.001
In our study we found that adropin was highly significantly negatively correlated with insulin concentrations
In our study we found a significant negative correlation between serum adropin and CIMT among T2DM without IHD
There is non significant difference between diabetics with and without IHD as regard carotid intima media thickness.
A diminished serum adropin concentration was associated with increased atherosclerosis manifestation as evidenced by a higher carotid intima media thickness and ischaemic heart disease in T2DM patients.
Adropin deficiency is possibly an independent risk factor for the development of atherosclerosis. At last, the converse link between serum adropin level and carotid intima media thickness evidences that adropin possibly supply an anti-atherosclerotic effect..