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العنوان
Comparison between the efficacy of topical tacrolimus, diclofenac 1% and clotrimazole in the treatment of tinea versicolor /
المؤلف
Amen, Nesma Mahdy Mohamed.
هيئة الاعداد
باحث / نسمة مهدى محمد امين
مشرف / عبدالعزيز ابراهيم الطويل
مشرف / رحاب محمد سالم
مشرف / عبدالعزيز ابراهيم الطويل
الموضوع
Tinea. Skin diseases diagnosis.
تاريخ النشر
2020.
عدد الصفحات
109 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأمراض الجلدية
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة بنها - كلية طب بشري - الجلدية والتناسلية
الفهرس
Only 14 pages are availabe for public view

from 105

from 105

Abstract

Fungus versicolor is a typical skin issue found in the every day dermatological practice. Fungus versicolor is an endogenous entrepreneurial contamination brought about by Malassezia yeasts, which are important for the typical verdure that regularly live on the skin.
A few foundational and skin medicines have been utilized in the treatment of fungus versicolor yet their utilization has been restricted close by impacts or variable restorative reactions, thusly there is progressing look for more secure and more successful medications.
There are provides details regarding the efficacies of moderately ongoing medications as tacrolimus salve and diclofenac 1% gel in the treatment of fungus versicolor in this way the current investigation intended to evaluate and think about the security and adequacy of tacrolimus 0.03% balm, diclofenac 1 % gel and clotrimazole 1% cream in the treatment of fungus versicolor.
This similar restorative investigation included 60 patients of fungus versicolor who were characterized into 3 gatherings: group An included 20 patients treated with tacrolimus 0.03% balm, group B included 20 patients treated with 1% diclofenac gel and group C (control gathering) included 20 patients treated with clotrimazole 0.1% cream. All medicines were applied topically twice every day for multi month. All patients were chosen from the outpatient facilities of Dermatology and Andrology Department of Benha University Hospitals. The investigation has been affirmed by the morals board of trustees on research including human subjects of Benha personnel of Medicine. Composed educated assents were gotten from the members. Every patient was exposed to full history taking, clinical assessment and wood’s light assessment before the beginning of treatment, two and a month after treatment. Patients were followed up multi month in the wake of halting the medicines.
Results:
•Clotrimazole indicated essentially better reaction both clinically and by wood’s light assessment contrasted with tacrolimus and diclofenac.
•In tacrolimus gathering, Hypopigmented fungus versicolor sores indicated preferable reaction over hyperpigmented fungus versicolor injuries after tacrolimus treatment by the fourth week both clinically and by wood’s light.
•In diclofenac gathering, Hyperpigmeted fungus versicolor indicated better reaction after diclofenac by the fourth week both clinically and by wood’s light assessment.
•In clotrimazole gathering, Hyperpigmeted fungus versicolor indicated better reaction after clotrimazole treatment by both clinically and by wood’s light assessment.
•All patients were surveyed for repeat following multi month, No critical contrasts were found between contemplated bunches which demonstrated the consistent antifungal movement after stoppage of the medication.
•There was inconsequential distinction in post pityriasis versicolor hypopigmentation in completely considered gatherings.
• Hyperpigmented type just as clotrimazole was related with better reaction to treatment in univariable examination. Nonetheless, taking critical covariates in univariable into multivariable investigation uncovered that clotrimazole was viewed as the main indicator for better reaction. Remarkably, the best reaction was credited to clotrimazole, trailed by tacrolimus. In univariable investigation, utilizing clotrimazole in hyperpigmented type may give the best outcomes. In multivariable examination, which focuses to free indicators, just clotrimazole was the main autonomous indicator.
•Insignificant results announced from drugs utilized in the examination.
•Tacrolimus balm and diclofenac 1% gelare compelling, protected and promising medications in treatment of pityriasis versicolor.
Ends
All in all, Tacrolimus balm and Diclofenac 1% gel appear to be protected, viable and cosmetically acknowledged medicines for fungus versicolor, anyway clotrimazole stays more powerful. Tacrolimus can be an appropriate adjuvant in instances of hypopigmented fungus versicolor. Likewise, diclofenac can be a reasonable adjuvant in hyperpigmented fungus versicolor particularly when obstruction or disappointment of the conventional medicines happens.
Suggestions
from the current outcomes, the current specialists would prescribe to lead:
•Comparative investigations utilizing various focuses and types of the current meds.
•Microbiological studies to look at the impact of various arrangements on the parasitic culture.
•Molecular studies to research theconnection between the medication viability and the contagious sorts by PCR.