الفهرس 
List of AbbreviationsOnly 14 pages are availabe for public view
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Abstract
Thioacetamide (TAA) is a specific hepatotoxic agent causing liver injury and dysfunction. While Moringea Oleifera (M.O) has been shown to have hepatoprotective activity. The current study was carried out to evaluate the protective potentials of M.O leaves ethanolic extract against TAA toxicity. 58 male albino rats were randomly assigned into six experimental groups. Control group were injected with distilled water. 2nd group, rats were injected with a single dose of TAA (200 mg/kg BW) i.p. 3rd group, rats were given M.O leaves ethanolic extract (300 mg/kg BW) orally. 4th group, rats were injected with a single dose of TAA as in the 2nd group and treated with M.O leaves ethanolic extract as in the 3rd group. 5th group, rats were kept for 26 days without treatment then on day 27th injected with TAA as in the 2nd group. 6th group, rats were administered M.O leaves ethanolic extract as in the 3rd group for 26 days then on day 27th intoxicated with TAA as in 2nd group. TAA intoxication significantly elevated activities of serum AST, ALT and ALP, concentrations of malonaldhyide and nitric oxide and protein expression of caspase-3 and COX-2 in hepatic tissues. In addition, it altered the histological structures of hepatic tissues. While it decreased serum levels of total protein and albumins and hepatic tissue contents of reduced glutathione. Finally, TAA intoxication resulted in 62.5% mortality in rats. In contrast, treatment of TAA intoxicated rats of the first experiment with M.O leaves ethanolic extract modulated the toxic effects of TAA on hepatic tissue structure and function as it enhanced GSH concentration in hepatic tissue and reduced pathological alterations, lipid peroxidation, caspase- 3 and COX- 2 proteins expression in hepatic tissue and serum activities of AST, ALT and ALP. Furthermore, M.O leaves ethanolic extract protected hepatic tissues of rats of the second experiment from TAA induced toxicity as it prevented TAA induced hepatic tissues injury and dysfunction and rescued rats from TAA induced mortality. In conculsion, M.O had ameliorating and protecting potentials against TAA induced liver damage through regulation of antioxidant, apoptotic and inflammatory markers.