الفهرس 
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Abstract
Summary
In spite of improvement of neonatal care over the past decades, infection is still considered common and sometimes life-threatening in neonates admitted to NICU. Neonatal sepsis is a clinical syndrome that is characterized by systemic signs of circulatory compromise resulted from bacterial invasion of the blood stream within the 1st 4 weeks of life.
The aim of the present study was to identify the incidence of sepsis among neonates admitted at Beni Suef University Hospital during the period of the study and identify various organisms account for sepsis among neonates at Beni Suef University Hospital. Furthermore, the serum level of CD14 (presepsin) was investigated as a biomarker of sepsis and its correlation with the type of underlying bacterial infection was assessed as well.
The total number of admitted neonates at NICU during the study period was 108 (47 Male & 61 Female) & average age was 19.7±6.8 days. By blood culture, the +ve cases were 35 cases representing (32.4%).
As regards the cause of admission, we found that (71.4%) of cases was admitted with respiratory distress followed by refusal of oral intake in (20%) of cases.
Klebsiella was the commonest organism isolated from blood (51.4%) followed by CONS (22.9%), pseudomonas (8.6%), enterococci (8.6%), MRSA (5.7%), Enterobacter (2.9%). This indicates that the majority of our cases resulted from by gram- negative bacteria.
We found that there was a statistically significant elevation of the CRP level among cases with sepsis in comparison with the control group (P-value<0.001).
The studied cases had higher level presepsin serum level in comparison with controls with statistically highly significant difference. According to our work at or > 2300 pg/ml presepsin can anticipate neonatal sepsis with 94.29% sensitivity and specificity of 88.57%.
Among all sepsis cases, 21 cases improved and 14 cases died. There was a statistically increased level of presepsin among cases with bad prognosis (died) when compared with who survived so presepsin has a good prognostic value to anticipate the fate of neonates with sepsis.