الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 145 |  |  |
| | | from | 145 | | |
Abstract
Hepatocellular carcinoma (HCC) was listed as the third most lethal cancer type. The most important risk factors for HCC include chronic viral hepatitis (types B and C), alcohol intake and aflatoxin exposure. In most cases, HCC is diagnosed at a late stage. AFP sensitivity for detecting HCC and its specificity is low. Early diagnosis of HCC and effective treatment are likely to prolong the lifetime of liver cancer patients. Thus, the identification of new high sensitivity and specificity markers for HCC is essential. The S100 protein family is one of the largest subfamily calcium-binding proteins. S100A14 is a member of S100 calcium-binding proteins, which is markedly up-regulated in several tumor tissues. Intracellular S100A14 promotes cell motility and invasiveness by regu¬lating the expression and function of matrix metallopro¬teinase (MMP)-2 in a p53-dependent manner. P53 is a transrepressor of MMP2 gene expression. Intracellu¬lar S100A14 affects p53 transactivity and stability, result¬ing in an enhancement of MMP2 gene expression.This study aimed to investigate the clinical significance of S100A14 in the diagnosis of hepatocellular carcinoma (HCC). S100A14 was significantly elevated in the HCC group. A cut-off value for serum S100A14 between the HCC group and cirrhosis group is ≥0.47 with a sensitivity of 100% and specificity of 88.57%. S100A14 level was a significant diagnostic factor for HCC and a good reference for HCC progression.