الفهرس 
صفحة العنوانOnly 14 pages are availabe for public view
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Abstract
Abstract
This study was carried out to investigate the bioactive effects of sesame seeds (raw, roasted and fermented) on atherosclerosis and inflammation induced rats. Adult male Sprague- Dawley rats (n= 72) were divided into two main groups the first main group (n=9) was fed on basal diet as a negative control group. Atherosclerosis was induced in the second main group (n = 63) which was divided into (7) groups, positive control group; the other six groups were treated with raw, roasted and fermented sesame seeds at two levels of intake (100 g/kg diet and 150 g/kg diet). At the end of the experimental period (8 weeks), feed intake was recorded and feed efficiency ratio was calculated. Organs (aorta, kidneys and liver) were collected. Blood samples were collected for estimating total cholesterol, triacylglycerols, total lipid, lipoprotein fractions, liver and kidney functions, Serum vitamin E and oxidative stress markers. Pedal inflammation was induced in atherosclerotic rats and Paw’s thickness was recoded. Results revealed that treatment of atherosclerotic rats with raw, roasted and fermented sesame seeds at the two levels of intake improved daily feed intake, body weight gain and feed efficiency ratio. Supplementation with all forms of sesame seeds improved blood lipids parameters and atherogenic index as well as caused an improvement in liver enzymes and kidney function as well as the activity of antioxidant enzymes in atherosclerotic rats. Results showed that the addition of sesame seeds led to a significant improvement in pedal inflammation in view of the positive effect of raw, roasted and fermented sesame seeds on most of the studied parameters. The results of histological studies were coincided with the biochemical analysis .The present study recommends increasing the consumption of sesame seeds in different forms. Nutrition education programs are needed to clarify the importance of sesame seeds in reducing the risk of developing arteriosclerosis and reducing inflammation. Further studies are required to evaluate the health benefits of consuming fermented sesame seeds.