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Abstract Myocardial infarction (MI) is the major cause of death and disability worldwide. MI is a complex disease characterized by the inheritance of multiple genetic variants acting in concert with environmental factors to promote the disease state . It causes energy depletion through imbalance between coronary blood supply and myocardial demand. Irisin is a newly discovered Myokine that is secreted by the heart, skeletal muscle, liver and kidneys and plays an important role in the homeostasis and metabolism of energy balance. It was reported that cardiac muscle produces more irisin than skeletal muscle . The aim of this study was to investigate the distribution of Irisin gene single nucleotide polymorphism in patients with MI and its association with other clinical and laboratory variables in these patients. |