الفهرس 
Chapter I: DIABETES MELLITUSOnly 14 pages are availabe for public view
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Abstract
The relationship between glycemic control and the risk of cardiac disease in patients with Type 2 Diabetes Mellitus (T2DM) is controversial. 1,5-Anhydroglucitol (1,5-AG) is a biomarker of Glucose Variability (GV) and has been associated with clinical cardiovascular disease. However, its association with Subclinical Cardiac Disease (SCD) is unknown. Study the association between GV and SCD. A cross-sectional case control study was conducted on 46 asymptomatic patients with T2DM as the patient group. Another 46 non-diabetic age and sex matched subjects were included as the control group. 1,5-AG , M-mode echocardiography and Global Longitudinal Strain (GLS) assessed by speckle tracking echocardiography were done to all subjects.
There were no significant differences between both groups as regarding age, sex, BMI, AST, ALT, and serum creatinine. 1,5-AG was lower in the patients group. .The patients group showed a statistically significant higher mitral valve area, apical 2 chambers, apical 4 chambers, apical longitudinal axis and GLS. No correlation found between HbA1c and any echo parameters while 1,5-AG showed a significantly negative correlation with apical 2 chambers, apical 4 chambers, apical longitudinal axis and GLS. ROC curve analysis detected 1,5-AG less than 7.51 ng/ml as the best cut off value with sensitivity of 85.7%, specificity 75% to diagnose patients with T2DM and SCD.
Patients with T2DM have SCD. SCD is associated with GV rather than hyperglycemia. 1,5-AG can predict patients with T2DM and SCD.