الفهرس 
IntrodtucrionOnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
Chlorpyrifos (CPF) is one of the most effective OPs insecticides used in agricultural and public health activities. CPF is an inhibitor of the enzyme acetylcholine esterase (AChE) such as well as other OPs and is involved in the major toxic effects on the nervous system. Lead is one of the oldest and most well-known metals in history related to the ability to form different alloys. Lead causes a variety of adverse effects on the reproductive system in both men and women. Lead mainly affects testicular spermatogenesis and also the sperms in the epididymis inducing reproductive toxicity.
Antioxidant is a reactive chemical such as vitamin E or a specialized enzyme such as catalase, and the body can produce enzymatic antioxidants but cannot create antioxidant chemicals (e.g. flavonoids, vitamin E and C) that protect cells in the body that are enzymatic antitoxins. Antioxidants are believed to play a very important role in the body defense mechanism against ROS. Quercetin is one of the most abundant dietary compounds classified as a flavanol which is one of the subclasses of flavonoids and are distributed widely among the fruits and vegetables.
The present study was undertaken to investigate the possible ameliorative effect of quercetin against chlorpyrifos (CPF), lead acetate (Pb) individually and their combination (CPF + Pb) induced neurotoxicity and reproductive toxicity in male rats.
Animals were divided randomly into 8 groups (6 animals each) of rats and treated as following: group I (control) was orally administered corn oil., group II was orally administered with a dose equaled to 50 mg/kg of body weight of quercetin., group III was orally administered with a dose equaled to 1.63 mg/kg of body weight of chlorpyrifos.,group IV was orally administered with a dose equaled to 10.8 mg/kg of body weight of lead acetate.