الفهرس 
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Abstract
Background: Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to an infective insult. This process often leads to widespread tissue injury and multiple organ dysfunction. In particular, the development of acute kidney injury (AKI) is one of the most frequent complications, which increases the complexity and cost of care, and is an independent risk factor for mortality (Umbro et al., 2016). In adult and pediatric data, sepsis accounts for 26% to 50% of all AKI in developed nations, compared with 7% to 10% of primary kidney disease–associated AKI (Bagshaw et al., 2008). Importantly, the development of AKI in the setting of sepsis increases the risk of in-hospital death six to eight-fold (Thakar et al., 2009), and among survivors, the risk of progression to chronic kidney disease (Murugan and Kellum, 2011). Many trials have identified potential biomarkers for the diagnosis and prognosis of sepsis-induced AKI. Biomarkers may facilitate the evaluation of sepsis progression and effective risk stratification. PCT has high accuracy for the diagnosis of bacterial sepsis in various settings. The elevated PCT concentrations were reported to be strongly associated with all-cause mortality in septic patients (Garnacho-Montero et al., 2014). In addition, patients at high risk of dying may have a persistently elevated PCT level. Thus, researches have reported that PCT non-clearance could also predict outcome of sepsis (Ulla et al., 2013). However, few studies have investigated the relationship between PCT levels and AKI, whether it adds a predictive or diagnostic value to commonly measured clinical variables and demographics or not. Patients and Methods: This study was conducted on 73 patients with sepsis induced AKI patients. All patients underwent a thorough clinical evaluation as well as laboratory tests including CBC, ABG, ESR, in addition to serum creatinine and urinalysis. Procalcitonin was evaluated upon admission. Severity of illness was evaluated by APACHE II score. All patients were prospectively followed from the time of diagnosis until discharge for the following outcomes: need for RRT, duration of hospital stay, fate of AKI either improved or worsened and mortality. Results: No statistically significant difference was noticed between patients who needed RRT and those who did not need as regard PCT level. Also, no statistically significant difference was found between the studied group of patients as regard the fate of AKI either improved, discharged on elevated serum creatinine, discharged on dialysis, or died in relation to PCT levels. PCT values demonstrated a statistically non-significant difference in relation to mortality of the studied patients. Conclusion: from the results of the current study, serum PCT level does not seem to have a role in predicting the severity of sepsis and the outcome in sepsis induced AKI patients.