الفهرس 
Introduction and Aim of WorkOnly 14 pages are availabe for public view
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Abstract
The study investigated cytotoxicity and induction of apoptosis in human cervical
cancer cells (HeLa), prostate cancer cells (PC-3), and colorectal cancer cells
(CACO-2) using the most active fraction of Moringa peregrina seed. 2 kg of dried
seed powder was extracted using 95% ethyl alcohol, followed by fractionated the
concentrated alcoholic extract into parts using polar gradient solvents, which are
petroleum ether, chloroform and ethyl acetate. Results showed that chloroform
fraction of ethanolic extract of Moringa peregrina seeds (high active antitumor
fraction) induce apoptotic effects on HeLa, PC-3 and CACO-2 confirming by
fragmentation of DNA on the agarose gel, increasing gene and protein expression
of Caspase-3, Decreasing in gene expression of BCL-2 and increasing in numbers
of early apoptotic cells and late apoptosis cells in cancer cells. In conclusion, Seed
extract of Moringa peregrina displayed a significant antitumor effect through
apoptosis induction in HELA, PC-3 and CACO-2 cancer cells.