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Abstract For the best of our information, this may be the first study to suggest that the antitumor effect of sulforaphane is related to a decreasing of the protein that regulates apoptosis, plectin. SFN anticancer effect against Ehrlich solid Tumor also involved molecular changes. These changes included the stimulation of antioxidant enzymes, as well as inhibition of inflammation and epigenetic modifications. The results of the study suggest that sulforaphane could be used as an adjuvant to anticancer drug or as a chemo-preventive agent against cancer. Moreover, this antitumor effect was also accompanied by notable fragmentation of DNA and changing in oxidative stress. SFN chemo preventive effect was better than the chemotherapeutic effect. Further evaluations thorough clinical trials are needed to confirm whether treatment by SFN is clinically relevant in human. Finally, it is recommended the public eating more cruciferous vegetables like cabbage in their daily diet. |