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العنوان
Biochemical Studies of the Curative Effect of Herbal Plants on Experimentally-Induced Solid Tumor /
المؤلف
Beltagy, Esraa-Eldin Risk Elsayed Elsayed.
هيئة الاعداد
باحث / إسراء الدين رزق السيد السيد بلتاجي
مشرف / إبراهيم فتوح حسن
مشرف / وفاء محمد أبراهيم
مشرف / طارق كمال أبوزيد
الموضوع
Biochemistry.
تاريخ النشر
2020.
عدد الصفحات
134 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
تاريخ الإجازة
31/12/2020
مكان الإجازة
جامعة كفر الشيخ - كلية الطب البيطري - قسم الكيمياء الحيوية
الفهرس
Only 14 pages are availabe for public view

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from 131

Abstract

For the best of our information, this may be the first study to suggest that the antitumor effect of sulforaphane is related to a decreasing of the protein that regulates apoptosis, plectin. SFN anticancer effect against Ehrlich solid Tumor also involved molecular changes. These changes included the stimulation of antioxidant enzymes, as well as inhibition of inflammation and epigenetic modifications. The results of the study suggest that sulforaphane could be used as an adjuvant to anticancer drug or as a chemo-preventive agent against cancer. Moreover, this antitumor effect was also accompanied by notable fragmentation of DNA and changing in oxidative stress. SFN chemo preventive effect was better than the chemotherapeutic effect. Further evaluations thorough clinical trials are needed to confirm whether treatment by SFN is clinically relevant in human. Finally, it is recommended the public eating more cruciferous vegetables like cabbage in their daily diet.