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Abstract Sirolimus is an immunosuppressive drug that inhibit the immune system via action on mTOR and thereby block activation of T and B cells .Sirolimus is widly used for prevention of graft rejection in organ and tissue transplantation . To investigate the effect of sirolimus on submandibular salivary gland of albino rats,fourty adult male albino rats with body weight ranging from 150-180 gram were used. The animals were divided into two equal groups 20 animals each . as follows : |