الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Young populations, especially the population ≤ 35 years of age, are often overlooked with respect to the diagnosis of coronary artery disease, even in individuals with multiple risk factors; however, studies have demonstrated that the incidence of coronary artery disease in young adults is following an ascending trend. Common risk factors for coronary artery disease, such as smoking, elevated body mass index, and diabetes mellitus, are known to be associated with occunrance of CAD even in young patients; however, recent studies have shown that non-traditional risk factors, such as hyperuricemia, may also play a role in the development of coronary artery disease. Smoking also approximately doubles the risk of morbidity and mortality from ischemic heart disease compared with a lifetime of not smoking, and the risk is related to the duration and amount of smoking. The main purpose of the study was to determine the following: 1) association between hyperuricemia and coronary artery disease; 2) interactive effect of both smoking and hyperuricemia on the risk for coronary artery disease in young adult‘s ≤ 35 years of age. This was a case control study was carried out at the department of cardiology, Tanta university hospitals. The duration of the study was 6 months. The study was included 100 subjects, from October 2019 till March 2020. All young adults (18–35 years of age) suspected to have CAD who underwent coronary angiography were included and all were subjected to the following: Summary and Conclusion 71 • Detailed history taking and full clinical examination. • Standard twelve-lead electrocardiogram. • Transthoracic two dimensional echocardiography. • Laboratory investigation: venous blood samples were obtained by the venipuncture of the large antecubital veins of the patients. Fasting blood sugar, random blood sugar, serum creatinine and blood urea, liver enzymes, lipid profile, cardiac enzymes and serum uric acid were obtained. • Coronary angiography: ascertainment of outcome coronary angiography and the presence of CAD was performed using (Gensini Score system) based on number of effected vessels, localization of the segment, and the grade of the stenosis. The presence of CAD has been defined as the Gensini score being > 0. Patients with the following condition were excluded from the study: • Renal impairment (an estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m2). • Active infections, autoimmune diseases or neoplastic disease. • Hepatic and hemolytic disorders. • Patient refusal. The main results of the study revealed that: 74 males and 26 females were included, with mean age 31.01±3.42 years. Regarding history taking there was 48% of the patients were smoker, there were also 23 diabetic patients, 14 patients have positive family history of CAD and 46 hypertensive patients among the studied patients. The most affected artery was LAD (56%) followed by RCA (40%). There is significant correlation between HUA and the occurrence of CAD in young adults ≤ 35 years old. The interaction between HUA and smoking has statistical significance for the occurrence of CAD in young adults ≤ 35 years old. HUA is significantly associated with the occurrence of CAD in nonsmokers young adults ≤ 35 years old. HUA isn‘t significantly associated with the occurrence of CAD in smokers young adults ≤ 35 years old.