الفهرس 
Seborrheic KeratosisOnly 14 pages are availabe for public view
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Abstract
In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8 weeks. Adobe photoshop CS6 was used to measure the surface area of the lesions before treatment and after 8 weeks. There was a highly statistically significant difference in the surface area of the lesions before and after treatment with topical diclofenac 1% gel ( P = .001) but there was no statistically significant difference with topical ibuprofen gel ( P = .057). There was a highly significant difference between the two treatment regimens as regard the percentage of change in surface area of the lesions, with higher change in the diclofenc 1% geltreated group ( P = .001). No patients complain from any side effect from either treatment.
In conclusion the current study showed that topical diclofenac sodium 1% gel is effective in treatment of SK without any side effects in comparison to topical ibuprofen gel.