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Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that can progress to cirrhosis. Vitamins E and C can be used in its treatment owing to their antioxidant effects. Prescriptive diet therapy also seems to have a promising effect in NAFLD management. Aim of the work: This cross-section study aims to comparison study between antioxidants therapy versus prescriptive diet therapy in nonalcoholic fatty liver patients. Patients and methods: This cross-sectional study including 90 patients who were divided into three groups (30 in each). The first group (nutritional therapy group) received nutritional therapy according Individualized nutritional therapy only, the second group (Vitamin C group) received nutritional therapy combined with dose of vitamin C (432 mg), while the third group (Vitamin E group) received nutritional therapy combined with high dose of vitamin E (40.6 mg) Follow-up continued for 3 months. Results: There were highly statistically significant differences before and after treatment with vitamin E and C and the nutritional therapy group in NAFLD patients as regards ALT, AST, hemoglobin, glucose, weight, body mass index (BMI), muscles, fats, target body weight(TBW), Waist-Hip Ratio (WHR) and ultrasonography findings. In addition, there were highly statistically significant differences between dose vitamins E and C and the nutritional therapy group. Conclusion: Vitamins E and C as well as prescriptive diet therapy induced significant improvement in hepatic condition in NAFLD patients in terms of biochemical, anthropometric measurements and ultrasonography findings; however Vitamin E and C had more significant results compared to the nutritional therapy group. Keywords: Vitamin E; Vitamin C; Prescriptive diet and Nonalcoholic fatty liver disease |