الفهرس 
Aim of the work
Literature Review of BacteriophagesOnly 14 pages are availabe for public view
 |  | from | 333 |  |  |
| | | from | 333 | | |
Abstract
Klebsiella is a one of the most common Gram-negative bacillus bacteria in the Enterobacteriaceae family. Medically, the most important species of this genus is K. pneumoniae, followed by K. oxytoca.
Klebsiella is a pathogenic microorganism that causes hospital-acquired Urinary Tract Infections (UTIs), pneumonia and septicemia. In recent times, community-acquired Pyogenic Liver Abscess (PLA) caused by
K. pneumoniae complicated with metastatic meningitis and endophthalmitis has emerged worldwide. K. pneumoniae is responsible for hospital-acquired bacterial infections, including pneumonia, bacteremia, urinary tract infections, liver abscess, and wound infections in immune compromised patients. It is also a particular problem for patients with diabetes mellitis leading to “diabetic foot” infections and osteomyelitis.
Multidrug-resistant bacteria are a pressing clinical issue, and yet few new antibiotics are being produced. Alternative strategies are needed for the control of pathogenic bacteria, and the use of bacteriophages offers an appealing alternative to small molecule antibiotics for controlling bacterial infections. Phage therapy is built on the premise that bacteriophages could be therapeutic by causing lysis of a sufficient percentage of host cells. Additionally, Klebsiella produces a polysaccharide capsule that contributes to biofilm formation and is essential for virulence and survival in mammalian tissues. A change in the interests of Klebsiella emerged worldwide since it was the major cause of high morbidity and mortality especially among intensive care unit (ICU) patients. Thus, disruption of the capsular polysaccharide of Klebsiella would also be valuable therapeutic strategy for combating
Klebsiella infections. This study aimed to isolate, characterize and use specific bacteriophages as biological control agent against human pathogen Klebsiella transmitted through infected patients.