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Abstract In vitro fertilization (IVF) has been performed for more than 40 years, and it is estimated that in developed countries, more than 1 % of all births are generated from assisted reproductive therapies (ART). Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. It is thought that vitamin D has an important role in reproduction processes and is significant in infertility therapy. Vitamin D levels are categorized into three groups; sufficient vitamin D, Insufficient vitamin D and deficient vitamin D. The aim of our study was to evaluate the correlation between vitamin D levels in the serum and follicular fluid in (ng/ml) and ICSI outcome. This prospective study was conducted on 50 patients undergoing ICSI, the inclusion criteria were: patient age ≤38 years, BMI 18-30, AMH level > 1.5 ng/ml, AFC) >10, unexplained infertility and tubal factor, the exclusion criteria were: azospermia, abnormal uterine cavity, endometriosis, PCOS patients and patients who received vitamin D supplement within 3 months before ICSI. All cases were stimulated by long GnRh agonist protocol and optimal HMG dose was chosen individually. ICSI was done and serum and follicular fluid samples were collected at time of OR, then analyzed for vitamin D levels. The women were followed to detect the occurrence of pregnancy by measuring serum B-hCG 14 days after embryo transfer and one week later. |