الفهرس 
Anatomy of the retinaOnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system associated with progressive neurodegeneration. Up till now, its pathogenesis is still not completely understood. Vascular abnormalities, which might depend on the abnormal function of cerebral endothelial cells, could play an important role in the pathogenesis of MS lesions and disease progression. Cerebral and retinal vasculature are anatomically interconnected and share similar features. Therefore, retinal vascular study in MS might reveal an underlying common pathology that connects inflammation to neurodegeneration through vascular alterations. Lesions of MS typically develop at different times and in different CNS locations (MS is said to be disseminated in time and space). MS attacks the myelinated axons in the CNS, destroying the myelin and the axons to varying degrees The retina can be considered a window into the brain. It is a good model for the study of neurodegeneration since it lacks myelin, meaning that changes in the GCL and RNFL thickness will be due only to axonal damage. The study was conducted on 20 eyes of patients with MS. 10 eyes of MS+ON patients and 10 eyes of MS-ON patients. 10 eyes of normal age matched control group. Summary 90 The aim of this study to correlate between structural changes in retina imaged by OCT (GCL and RNFL) and optic nerve perfusion measured by OCTA in MS patients. We studied OCT findings of MS patients (average GCL thickness and average RNFL thickness), OCTA findings (ONH & macular perfusion). We reported a statistical significant thinning of GCL and RNFL in MS patient especially MS +ON more than normal subjects. A correlation between OCT parameters (average RNFL and GCL thickness) ,visual acuity ,disease duration and EDSS was noticed especially with GCL thickness suggesting that GCIPL thickness may have superior structure function relationships than RNFL thickness also potentially related to better reproducibility and reliability. We reported a statistical significant reduction of optic nerve head vessel density in MS patients with or without optic neuritis .The reduction was in both superficial and deep vascular plexus. However, macular vessel density wasn’t affected. This study shows correlation between OCTA results (decreased ONH vessel density) and OCT results (decreased both RNFLT and GCLT) in MS. ONH vessel density also has significant correlation with visual acuity and disease duration. There is no significant correlation between ONH vessel density and disability scale (EDSS) in MS patients.