الفهرس 
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Abstract
Objectives : The present study was carried out using two plants belong to family lamiaceae including Melissa officinalis (MO) and mentha longifolia (ML). Five extracts were obtained from dried leaves of plants by successive extraction for crude methanol extract which named pet. ether, methylene chloride, ethyl acetate, butanol and methanol extracts. chemical analysis were determined as following: Total Phenolics and flavonoids content - Antioxidant Activity - Effect of plant methanolic extracts on experimental animals infected with diabetes mellitus. Methods and Results: Total phenolic content of M. officinalis extracts gave a reduction values as follows : started with ethyl acetate, butanol, methanol , methylene chloride , pet. ether. Average values of 143.50, 93.88, 71.02, 41.6 and 32.44 mg GAE/g were detected, respectively. While, in M. longifolia extracts phenolic content decreased in order of ethyl acetate, methylene chloride, methanol, butanol, pet. ether. Average value of 228.36, 190.26, 189.8, 171.26 and 154.56 mg GAE/g were found, respectively. Total flavonoids content (TFC) of M. officinalis extracts showed that ethyl acetate extract had the highest value with 124.96 mg QE/g followed by butanol, methanol, methylene chloride and pet. ether extracts with average values of 84.96, 72.38, 59.76 and 45.44 mg QE/g, respectively . While, the highest TFC value of M. longifolia extracts was detected for pet. ether with average value of 293.86 mg QE/g followed by methylene chloride, methanol, ethyl acetate and butanol with average values of 236.23, 207.43, 182.73 and 153.39 mg QE/g, respectively. The radical scavenging activities (DPPH) of M. officinalis extracts decreased as follows : ethyl acetate, butanol, methanol, methylene chloride and pet. ether with average values IC50 of 83.95, 94.58, 125.72, 146.67 and 905.79 μg/mL, respectively . While, M. longifolia extracts showed a reduction started with ethyl acetate extract, pet. ether, butanol, methylene chloride and methanol with average values IC50 of 107.01, 109.89, 115.68, 124.19 and 136.83 μg/mL, respectively. Regarding plasma glucose levels of animal treated with M. officinalis methanol extract, it was observed that the highest effect was noticed in group 4 then group 3 and group 5 where plasma glucose showed a decrease percentage values of 66.02, 61.51and 57.28,respectively. While, in case M. longifolia, the maximum effect was observed in group 6 followed by 7 and 8 where plasma glucose lowed by 54.27, 42.07and 28.28 %, respectively, after 6 week in comparison with 0 time.