الفهرس 
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Abstract
T1D is the most common chronic metabolic autoimmune disease. Several studies had shown that T1D is associated with metabolic abnormalities and alteration of immunoglobulins.
The aim of our study was to screen for Islet cell antibodies in non-diabetic siblings of children with T1D and their correlation to different clinical and laboratory parameters.
Our study included two groups; group I: 60 children with a first degree relative with T1D, who had regular follow up in the diabetes outpatient’s clinic, Minia University children hospital. group II: 60 apparently healthy children with negative history of T1D in their siblings, age and sex matched with the previous group.
In the current study, we found that fasting blood glucose level and HbA1c were significantly higher in the first-degree siblings of T1D group than the control group. In addition, we found that siblings of diabetic children had significant higher percentage of ICA positivity compared to the control subjects.
Finally ICA positivity had a significant moderate negative correlation with fasting C-peptide.