الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Mini-implants have been newly developed in orthodontics, providing a reliable fixed anchorage point and as a result, our biomechanics becomes more predictable. However, instability of mini-implants at the placement site is noticed during orthodontic treatment. Thus, the ability to use platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) represents a new potential treatment opportunity for implant stability. Therefore, the present study was undertaken to estimate the effect of either platelet-rich plasma (PRP) or PRP with stem cells on orthodontic mini-implants osseointegration. Nine mature dogs classified into three groups were control, PRP group, and PRP with stem cells group, respectively. MSCs were isolated from dog’s adipose tissue and cultured for 3 weeks before implantation. A total of twenty-seven self-drilling mini-implants were used. Two mini-implant was inserted in the right femur of each dog (one for a control group and second for PRP group). Moreover, one mini-implant was inserted in the left femur of each dog in PRP with MSCs group. Predrilling and tested materials injection preceded implant insertion. The implants were examined by histological and digital morphometric analysis on 1, 2, and 4 weeks after implantation. Our data indicate that PRP with stem cells treatment resulted in increased bone formation around mini-implants compared to the control and PRP groups. Our findings strongly suggest that bone tissue-engineering may be sufficient for accelerating and increasing bone formation around mini-implant during orthodontic treatment.