الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Background: One of the common treatment modalities of OA is the intra-articular injection as it
provides local drug delivery to the joint with instant pain relief. The aim of this study was to investigate
the reparative potential of intraarticular injections of PRP, Botox and the Botox+PRP (combined) in
treating induced TMJOA in Albino rats.
Methods: 60 male adult Wister albino rats were used in this study. All rats were anesthetized and injected
with 2mg MIA in both sides of TMJ to induce OA. After confirmation of OA by ELISA, the rats were
divided to 3 groups (n=20/group) the right side acted as the experimental group and the left side as the
control. All rats were euthanized at 6 & 8 weeks and the tissues were then assessed histologically,
histochemically, biochemically (qRT-PCR, ELISA), radiographically (CBCT) and statistically.
Results: In all groups after 6 or 8 weeks, the experimental side showed statistically significantly higher
mean bone area %, mean cartilage area %, mean joint space and lower mean IL-1β and MMP13 levels
than the control side. The highest mean bone and cartilage area percentage were recorded in the PRP
group followed by the combined group of Botox+PRP.
Conclusion: The study results have confirmed the healing potential of PRP and combined Botox+PRP
by the different used analysis methods. This implies that the use of PRP alone or combined with Botox
for treatment of cases of TMJ osteoarthritis can enhance and hasten the healing of conditions as TMJ OA.