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Abstract Summary and conclusion The pterygopalatine fossa (PPF) is an obscure but important space in the region of deep face that needs to be evaluated very carefully in the head and neck imaging, since many infective, inflammatory, and neoplastic conditions can affect it. The anatomical variations and morphometric analysis of the pterygopalatine fossa (PPF) and its communications have important clinical applications for palatal surgery, periodontal surgery, Caldwell-Luc procedure, quadrant restorative dentistry of the maxilla and multiple dental extractions. The PPF evaluation helps in treating many diseases as resistant vasomotor and allergic rhinitis. Its evaluation also, assists in plastic interventions, maxillary sinus exploration, dental implantations and orbital procedures. Aim of the work The aim of this study was to map the anatomical variations of the pterygopalatine fossa and its communications using computed tomography (CT) to act as a base for an Egyptian guideline to plastic, maxillofacial surgeons and dental clinicians, also it was compared with the already existing anatomical data in other races and populations. Subjects and methods: This study was done at the CT scanning unit in the Radiology Department, Tanta University Hospital. The CT images were acquired using a GE optima 660 (128 MDCT) and a Toshiba Aquilion one (320 MDCT). The following study parameters were applied: exposure 120 kV, 74 Ma and |