الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
A corrosive is any substance that can destroy tissue chemically. Caustic ingestion is still considered a significant medical problem despite the efforts done to reduce exposure to the corrosive household products. The epidemiology of caustic exposures has changed over the years. The introduction of new cleaning products to the public, notably liquid lye in 1967, increased the incidence of caustic ingestions (Shub, 2015 and Calello, 2017). Corrosive agents can be classified into two main types; acids or alkalis. Acids and alkali agents have contrasting characteristics and differ in how they cause tissue damage. Alkaline agents are usually colorless, relatively tasteless, more viscous having a less marked odor, hence the amount ingested tends to be more. Once ingested, alkaline substances react with proteins and fats and are transformed into proteinases and soaps, resulting in liquefactive necrosis. This leads to deeper penetration into tissues with a greater likelihood of transmural injury. On the other hand, acids have a pungent odor and an unpleasant taste. They tend to be consumed in smaller amounts and are swallowed rapidly after ingestion. Once it reacts with tissue proteins, these substances are converted to acid proteins. The mode of tissue injury is coagulation necrosis. The coagulum prevents the corrosive agent from spreading transmurally, hence reducing the incidence of full thickness injury (De Lusong et al., 2017). Because of the lack of controlled studies, management of corrosive ingestion depends mainly on observational data and clinical experience. Protocols have been made on the basis of perceived successful outcomes. The cornerstone for the management of all caustic ingestions is airway and hemodynamic stabilization and pain killer administration. Initiation of proton pump inhibitors and H2 blockers is recommended after caustic ingestion to minimize the reflux of gastric contents into the oesophagus, thereby minimizing oesophageal injury. Data concerning the use of antibiotics are scares and the role of antibiotics in stricture prevention is less clear. Currently there is no sufficient human data to support the global use of antibiotics in patients with caustic ingestion (Shub, 2015 and Ayesh & Sultan, 2017). Honey is produced by the bees from the genus Apis, that collect nectar and pollen grains from the plants. It is a sweet natural product which is highly saturated in sugars with high nutritive value. Beside sugar, other minor components are present in honey, such as: minerals, vitamins, polyphenols, carotenoids, proteins, amino acids, enzymes, organic acids and volatile compounds. from the ancient time and nowadays, honey has been used in accelerating the wound healing process. Honey significantly contributes in the healing of wounds due to its antimicrobial, antioxidant and anti-inflammatory activities, boosting effect on immune system, debridement action and its role in stimulating wound regeneration (Oryan et al., 2016 and Miguel et al., 2017). Hence, the aim of the present study was to assess the role of honey as an adjuvant therapy in acute potassium hydroxide poisoning in adult male albino rats.