الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Many herbal products have been used to control blood glucose level and minimize complications of diabetes mellitus. However, the feasibility of using such herbal product has been hindered due to the lower stability of their extracts and patients incompliance.
Objective: An optimized fast disintegrating tablet preparation of spray dried aqueous extract of poly herbal blend has been formulated to maximize the therapeutic activity of such herbal extract.
Methods: different ratios of superdisintegrants were evaluated in terms of reducing disintegration time and wetting time of the prepared formulations. The potential of the optimized formula in reducing blood glucose level and promoting wound healing in streptozotcin (STZ)-induced diabetic rats was determined.
Key finding: Oral administration of the optimized formula (F6) had significant superior effect in reducing blood glucose level and promoting wound healing of diabetic rats compared receiving the aqueous extract of the herbal blend (P<0.05, p<0.01, respectively). That may be attributed to the enhanced stability and the accurate dosing of such solid dosage form. In addition, no remarkable toxic manifestations or histologic changes were observed in treated animals.
Conclusion:
These findings demonstrate the promising potential of the formulated dosage form in the enhancement of the treatment of hyperglycemia and wound healing activity using the studied herbal extract. The aqueous extract of the herbal blend was given on a daily basis to ten volunteers afflicted with diabetes that was accompanied by diabetic foot ulcer (28.75 mg/kg). Treatment was maintained for 6 successive months. At the same time, tested patients were kept on their anti-diabetic treatment and blood glucose level was monitored daily. Improvements in diabetic wound healing were monitored weekly.