الفهرس 
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Abstract
The objective of this work is to prepare and evaluate anticancer activities of some new heterocyclic compounds containing thiophene and its bioisosteres. Computational studies of the target compounds to compare experimental and theoretical data. Linking chemistry of the compounds to biology to establish the structure activity relationship. The present work of this thesis was divided into 3 parts:Part I: Chemical reactivity Part II: Computational studiesPart III: Biological assessmentPart I was subdivided into 3 sections Section 1. Target compounds thienylnicotinamidines 5a-jThe preparation of the new thienylnicotinamidines 5a-j (Scheme 1) begins with either Suzuki coupling reaction of bromothienyl derivative 2a with the appropriate phenylboronic acids 3a-i or adopting Heck coupling reaction of thienyl derivative 1a with 1-bromo-3,5-dichlorobenzene to furnish the thienylnicotinonitriles 4a-j. The nicotinonitriles 4a-j were converted to the corresponding nicotinamidine derivatives 5a-j by the action of lithium trimethylsilylamide [LiN(TMS)2] in THF, followed by de-protection with hydrogen chloride. The resultant precipitate was neutralized with 1N NaOH to furnish the corresponding free bases of thienylnicotinamidines 5a-j. The monoamidines hydrochloride salts were prepared by treatment of the proper free base of monoamidines with hydrogen chloride in ethanol.