الفهرس 
Hair Biology
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Abstract
Female pattern hair loss (FPHL) is the most common cause of alopecia in women, characterized by diffuse nonscarring hair loss in frontal, central, and parietal areas of the scalp. Pathophysiology of FPHL is still not well known, and it is probably a multifactorial genetic trait. FPHL is also observed in women without increased androgen levels, which raises the likelihood of androgenindependent mechanisms and explains the lack of response to antiandrogen treatments in some patients. Vitamin D is a factor that has recently been considered in dealing with these patients. This study was conducted at Tanta University hospitals aiming to evaluate the serum level of 25 hydroxy vitamin D in patients with FPHL to elucidate its possible role in the pathogenesis of the disease and also to evaluate the efficacy of vitamin D therapy alone or combined with minixodil in the treatment of the disease. This study included 45 patients with female pattern hair loss (FPHL) and 15 healthy controls. The cases were furtherly subdivided into three subgroups; group I included 15 cases who received both topical minoxidil and oral vitamin D, group II included 15 cases who received only topical minoxidil, and group III which included the remaining 15 cases who were commenced on oral vitamin D alone. All cases were subjected to complete history taking, thorough physical examination, and routine dermatological examination for other lesions. Besides, dermoscopy was performed for all cases, and grading Ludwig grading. Serum vitamin D level was ordered for cases and controls. There was no significant difference between the three cases subgroups regarding demographics, medical history, and family history. In addition, Ludwig grade did not differ significantly between these subgroups. Regarding vitamin D levels, it had significantly lower levels in cases compared to controls, even after treatment. However, patients showed significant improvement of vitamin D levels after treatment. This improvement was not statistically different between the two subgroups who received vitamin D therapy. As regard Ludwig scale, there was statistically improvement in the three groups with more improvement in group I than II while there was no significant improvement in group III. The dermoscopic findings, analysis revealed that thin hair was significantly improved in subgroups I and II, while it was not significantly changed in group III. The same findings were detected regarding single hair unit. As regard correlation between vitamin D and Ludwig grading and other dermoscopic signs of FPHL, there was no significant correlation between vitamin D level and these parameters before and after therapy.