الفهرس 
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Abstract
This study was implemented on 40 male rats which were divided into 4 groups, 10 rats in each group : - group 1: control group fed on a normal diet. - group 2: control diabetic, fed on a high fat diet to induce obesity then experimental diabetes. -group 3: obese-diabetic (treated group), fed on high fat diet for 2 wk to induce obesity, followed by stz injection at low dose (35 mg/kg), with oral administration of P.harmala extract at dose (150 mg/kg), each rat take 2 ml by using gavage. - group 4: obese-diabetic (treated group), fed on high fat diet for 2 wk to induce obesity, followed by stz injection at low dose (35 mg/kg) for experimental type2 diabetes, with oral administration of P.harmala extract at dose (250 mg/kg), each rat take 2 ml by using stomach gavage. After 4 wk of treatment period rats were fasted overnight for sacrificing, anesthetized for collecting blood samples, then liver and adipose tissue were collected. The P.harmala improve the genetic expression and regulation of PPAR-gamma which act to suppress hyperglycemia occurred with type 2 diabetes mellitus and P.harmala contain harmine which elevated effect of PPARγ on adipocyte and increase its expression, PPARγ acts as a master transcriptional regulator of adipogenesis and plays important role for maintenance the function of adipocytes like, synthesis and storage of triglycerides also control genes which encode enzymes that participated in fatty acids esterification.