الفهرس 
COMMUNITY ACQUIRED URINARY TRACT INFECTIONOnly 14 pages are availabe for public view
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Abstract
Background: Urinary tract infections (UTIs) are among the most common bacterial infections diagnosed in community health practice and also of the hospital settings, resulting in high rates of morbidity and high economic costs associated with its treatment. The most frequent uropathogen involved in community-acquired UTI is E. coli (80-90%) due to the fact established being a normal flora of the human intestine and therefore easily colonizing the urinary tract. Other causative organisms are members of Enterobacteriacae family and some Gram positive agents like Staphylococcus saprophyticus and Enterococcus faecalis. In order to administer an appropriate empirical therapy it is crucial to know the main bacteria usually involved in the UTI as well as their antimicrobial resistance pattern
Aim of the Work: To determine the implicated uropathogens associated with community-acquired UTIs and their respective antimicrobial resistance pattern to improve the efficacy of empirical treatment of this infection.
Patients and Methods: This a cross-sectional descriptive study study was conducted from November 2018 to November 2019 at the main Microbiology Lab in Clinical Pathology Department, Ain Shams University Hospitals. Samples were received from patients attending different outpatient clinics in Ain Shams University Hospitals having UTI symptoms and whose urine samples showed significant bacterial growth (≥105 CFU/mL) associated with a white blood cell count more than 8–10 pus cells by microscopic urine analysis and nitrite and leukocyte esterase positive by chemical analysis of urine strip.
Results: A total of 1600 patients who fulfilled our inclusion criteria were sampled. Of these, 1058 patients had urine samples that showed significant bacterial growth while about 34% of the samples were contaminated. Of the 1058 significant samples, 764 (72.21%) were from females and 294 (27.79%) from males with female to male ratio 2.6:1. Escherichia coli was found the dominant bacteria among a with the prevalence rate of 24.4% followed by Klebsiella pneumoniae (13.8%). Tetracycline was found the most resistant drug 929 (95.4%) followed by Ampicillin (90.1%) then Tazobactam-piperacillin (81.7%); however, the most sensitive drug against all uropathogens was Ertapenem (72.9%) followed by Imipenem (66.5%), Meropenem (66.4%) and Amikacin showing 58.01% sensitivity (Table 4). For gram positive uropathogens Linezolid showed the highest sensitivity about 84%.
Conclusion: The present study reveals a familiar pattern with respect to the species of uropathogens involved in community acquired urinary tract infections, and it showed considerable bacterial resistance to common empirically prescribed antibiotics.