الفهرس 
Conscious Sedation
Patients and MethodsOnly 14 pages are availabe for public view
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Abstract
ataract extraction surgery is the most common ophthalmic surgery. Optimum sedation during cataract surgery must provide anxiolysis, amnesia, without loss of protective airway reflexes, respiratory depression or serious hemodynamic complications.
Pregabalin has sedative and anxiolytic effects as oral premedicants and decreases the need for intraoperative analgesic drug requirement. It also decreases the need for analgesics in postoperative period. The present study evaluated the clinical efficacy of oral premedication with pregabalin for providing sedation during surgery.
It also aimed at assessing the perioperative analgesic consumption in patients undergoing cataract surgery. A total of 60 healthy adult consented patients aged 18 to 80 years with American Society of Anesthesiologist (ASA) I and II physical status of both sexes, who were scheduled for elective cataract surgery, were randomized to receive pregabalin (150 mg) group or placebo group given 1 hour before surgery as oral premedication. Anesthetic technique was standardized and all groups were assessed for preoperative sedation and anxiety level, Verbal Pain Scale (VPS) along with changes of heart rate and mean arterial pressure prior to premedication, 1 hour after premedication, on arrival to operating room, intraoperatively every 5 minute. Intraoperative analgesic drug requirement and any postoperative complications were also recorded. Patients were studied at 6, 12, 18 and 24 h postoperatively and pethidine consumption.
Pre-operative sedation levels were higher with pregabalin than Placebo as oral premedicants. Significant increase in heart rate and mean arterial pressure was observed in control group 1 hour after premedication and on arrival to operating room, while statistically insignificant difference of mean arterial pressure and hemodynamics intraoperatively and first 24 hour postoperatively. But there was stastistically decrease of hemodynamics compared to baseline in both groups. The VPS scores of the pregabalin group were significantly lower than the control group at all time of measurements.
The total intraoperative fentanyl and postoperative pethidine consumption of premedicated groups were significantly lower than the control group. Dizziness was higher in pregabalin group while bradycardia was the same in both groups.the total dexmetedemidine consumption was higher in control group.
Oral premedication with pregabalin 150 mg causes sedation and anxiolysis with hemodynamic stability during cataract surgery under topical anesthesia, without respiratory depression.