الفهرس 
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Abstract
Summary
Neonatal sepsis is a clinical disorder developed by bacterial blood stream infections (BSI) in neonates. It is a dangerous and common disease among infants which is associated with high morbidity and mortality.
Although blood culture has been considered as the gold standard, this analysis is still too slow and limited by false negative results. There has been constant search of an ideal sepsis biomarker that have high sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).
The most commonly used biomarkers are C-reactive protein (CRP) and procalcitonin (PCT), but both have shown varied sensitivity, specificity, PPV and NPV in different studies.
In neonatal sepsis, Inflammation and coagulation can activate each other. Coagulation activation can occur in the early phase of sepsis.
Mean platelet volume (MPV) is a measure of platelet volume. It reveals the presence of inflammatory burden and disease activity in many diseases.
The aim of this study was to assess platelets function in neonatal sepsis.
This study was a case control study which included 50 patients with neonatal sepsis. In addition, there was 50 age and sex matched healthy neonates who served as controls. Patients were selected on the basis of the following criteria:
Inclusion criteria
Neonates with neonatal sepsis: A diagnosis of clinical sepsis requires the presence of at least three of the following: bradycardia (< 100/min), hypotension, hypotonia, seizures, apnea, tachypnea, cyanosis, respiratory distress, poor skin color and perfusion, feeding difficulty, irritability, lethargy in addition to laboratory results showing elevated levels of CRP or IL-6. Patients with culture positivity were accepted as proven sepsis.
Exclusion criteria
Undergoing a course of antibiotics prior to appropriate blood sampling
Undergoing surgery in the previous week
Chromosomal abnormality
Lack of informed consent from the parents
Inadequate blood sampling for all tests.
II. METHODS
All participants were subjected to the following:
Careful history taking.
Thorough clinical examination.
Laboratory investigations: CBC, CRP and blood culture.
Assessment of mean platelets volume.
Platlets function test.
The results of our present study can be summarized as follows:
mean value of platelet count was statistically significant lower among cases than controls (P<0.05)
MPV was significantly higher in patients than controls (P<0.05).
mean value of PDW was statistically significant lower among cases than controls (P<0.05)
As regard CRP level which was positive in (90%) of patients group.
About 68% had negative blood cultures and 32% of the case group had positive blood cultures; Klebsiella was the most common organisms in our patients followed by E. coli.