الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Ulcerative colitis (UC) is one of the IBDs with multitude of multisystem group of disorders with specific clinical and pathological features. Despite improved understanding of the genetics and inflammatory mechanisms that underly this disease, however, the etiology and pathogenesis of ulcerative colitis remain undefined with interaction between environmental, genetic and immunological factors being the most accepted explanation
Diagnosis of UC is based on laboratory findings such as Complete blood count, acute phase proteins (CRP and ESR), albumin and other serological markers (ANCA), together with fecal markers such as stool calprotectin, and lactoferrin. however, ileocolonoscopy is the best tool for making the diagnosis of UC as it allows direct visualization of the colon. multiple tissue biopsies can be taken from both involved and uninvolved sites for histopathologic analysis to confirm the diagnosis, radiological modalities used for diagnosis and assessment of UC include CTE Enterography (CTE) and MR enterography (MRE).
MicroRNA (miRNA) are small, highly conserved, single -stranded, non-coding RNA molecules that bind target mRNA to prevent protein production.
miRNA expression in the peripheral blood from patients with IBD have been examined in several recent analyses. The expression of miRNAs in plasma and serum were thought to reflect the extrusion of miRNAs from relevant remote tissues or organs. Initial studies found dissimilar miRNA expression profiles compared with tissues, leading to the suggestion that peripheral blood miRNAs may reflect circulating leukocytes rather than expression in remote tissues.
The aim of the current study is to assess the expression of miRNA-16 in the serum of patients with UC and its correlation with disease severity and extent.
This study included patients’ group of thirty treatment naïve patients with established UC of different stages and presentations and control group of twenty healthy subjects. They were recruited at Gastroenterology unit, Internal Medicine Department of Alexandria Main University Hospital
The mean serum miRNA-16 for the patients was highrt than that for the controls was with significant difference between patients and control group.