الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Guillain-Barré syndrome is acute polyradiculoneuropathy with a variable clinical presentation.
GBS is often triggered by an infectious process, and it affects children of all ages. Once considered a single disease, many subtypes have been identified based on the neuronal components involved. Trials of immunotherapy (intravenous immunoglobulin) or plasma exchange in Guillain-Barré syndrome are difficult to organize, complex, and expensive.
Up to our knowledge regarding our local context, there are no valid good quality evidence based clinical practice guideline in this topic of pediatrics and no resources to develop de-novo CPG of good quality. That’s why there was a great need to adapt or adopt current available CPG to the local setting to improve the clinical practice.
The trend of the last decades has been to base clinical decision making more and more on sound scientific evidence i.e. evidence based medicine in practice this has led medical specialists to develop evidence based clinical practice guidelines (CPG) for promoting standards of medical care. worldwide a number of organization such as SIGN(Scottish Intercollegiate Guidelines Network) and CBO(Dutch Institute for Health Care Improvement).In 2002 the Guidelines International Network was founded to promote systematic development of CPG through international collaboration.
One way to reduce the costs and time, avoid variations of institutions setting, such as type of practice and location, consider availability of resources, respect local policies and practice patterns is by relying on local adaptation of guidelines developed at the international level by expert groups.
Therefore clinical guidelines developed by the government agencies or medical specialty organizations at the national level usually need to be adapted to fit the local practice before they can be actually used by clinicians at specific institutions and successful guideline implementation has to be supported by organizational efforts.