الفهرس 
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Abstract
Background:. Proliferative diabetic retinopathy (PDR) is considered one of the leading causes of vision loss in patients with diabetes mellitus. Neo vascularisation is the hall mark of PDR and the new vessels may develop on the disc (NVD) or elsewhere on the retina (NVE). Recently developed OCT angiography techniques are widely spreading in clinical practice as noninvasive three-dimensional techniques for chorioretinal vascular imaging which can clearly visualize the microvascular structures of neovascularization and can also directly visualize well-delineated microvascular structures of new vessels and differentiate them from original retinal vascular structures without having the effect of fluorescein leakage which gives OCT angiography an advantage over fluorescein angiography. This study aimed to evaluate the role of Swept Source Optical Coherence Tomography Angiography in detection and characterization of new vessels at the disc (NVD) and new vessels elsewhere (NVE) in eyes with proliferative diabetic retinopathy and center-involving diabetic macular edema which was held on 50 eyes of cases attending to Mansoura ophthalmic center –Mansoura University with proliferative diabetic changes detected in the form of NVD in 26 cases (52%) , NVE in 14 cases (28%) and both in 10 cases(20%) imaged with OCTA, using DRI OCT Triton series Swept source optical coherence tomography (Topcon, Tokyo, Japan). History was taken and full examination were done for all cases. Fundus Flourescein angiography (FFA) was also done for all cases. It was observed that OCTA could nearly identify most of the neo vessels shown by FA in the form of NVD in all affected cases(100%) and NVEs in 16 cases (66.67%) of affected cases. In this study it was noted that new vessels in patients with untreated PDR had the sign of EVP, which is the intense growth of irregular small-caliber vessels located at the margin of new vessels, likely represents active proliferation. It also could detect irregularities in all retinal layers. Also, NVEs could be differentiated into 3 types according to their origin and morphology. Also, OCTA was used to measure areas of neo vessels which can be used as a guidance in treatment journey of the patients.