الفهرس 
1. INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
This study was carried out to evaluate the antihypercholesterolemic and diabetic rats effects of Menthe spicata L., Salvia officinalis L. and Abelmoschus esculentus leaves. 60 male mature albino rats weighing 150-160g per each, were used in this study and divided into three groups, the first group was kept as a control (-ve) group (n=4), while the groups were fed on hypercholesterolemic diet (n=28) for 3 weeks to induce hypercholesterolemic rats and the diabetic groups (n=28) injection of freshly prepared solution of alloxan monohydrate at a dose of 150 mg/kg b.w. The tested plant leaves powder (PLP) were given to the rats as a percent of 3 and 6% from the Basel diet for 28 days . At the end of the experiment, serum Total cholesretol(TC), Triglycerides(TG), High density lipoprotein (HDL-c), AST, ALT, ALP, urea, creatinin, uric acid were determined Low density lipoprotein(LDL-c) ,Verylow density lipoprotein (VLDL-c) , and A.I were calculated.The results of the obtained data indicated that tested plant leaves significantly (P≤0.05) decreased serum TC, TG, LDL, VLDL and increased HDL. Also, the tested plants leaves improved liver and kidney functions and prevent some of the adverse histopathological changes in heart. The obtained findings hypothesis that tested plant leaves containing several compounds those are able to improve the adverse effects and inhibited hypercholesterolemic and diabetes rats.So the data recommended such plants by a moderate amounts in our diets, are more benfites.
Rats were divided into three main groups as following:
-The frist main group:(n=4) was fed on the basal diet as control negative .
-The second main group:(n=28) hyperlipidemic rats in this group rats were fed on high fat diet by 10 % for three weeks , then divided into 7 subgroups as following :
- hyperlipidemic rats + basal diet (positive control) .
- hyperlipidemic rats + basal diet containing 3% Common Sage .
- hyperlipidemic rats + basal diet containing 6% Common Sage .
- hyperlipidemic rats + basal diet containing 3% spearmint .
- hyperlipidemic rats + basal diet containing 6% spearmint .
- hyperlipidemic rats + basal diet containing 3% Okra .
- hyperlipidemic rats + basal diet containing 3% Okra .
-The third main group:(n=28) diabetes rats in this group rats were Injected by Alloxan by 150 mg/kg body weight then divided into 7 subgroups as following :
- diabetes rats + basal diet (positive control) .
- diabetes rats + basal diet containing 3% Common Sage .
- diabetes rats + basal diet containing 6% Common Sage .
- diabetes rats + basal diet containing 3% spearmint .
- diabetes rats + basal diet containing 6% spearmint .
- diabetes rats + basal diet containing 3% Okra .
- diabetes rats + basal diet containing 3% Okra .
4.7. Statistical Analysis : All statistical analysis was done using statistical package for social sciences (SPSS) version, 17.0 windows and differences in means were compared using the students’ t-test and one-way analysis of variance (ANOVA) Error of probability or (p≤0.05) was considered significant .
The obtained results can be summarized as following:
Firstly: The Biological Results.
The effect of experimental diets on BWG%, F.I, and F.E.R:
The mean value of body weight gain (B.W.G%) of negative control was significantly (p≤0.05) higher when compared with positive control whearease the mean value of treated groups was significantly lower when compared with positive control on diabetic and hyperlipidemic rats.
The mean value of feed intake (F.I) of all groups were significantly lower when compared with positive control except group which treated spearment 6% .
The mean value of feed efficiency ratio (FER) for all treated groups were significantly lower (p≤0.05) when compared with positive control in hyperlipidemic rats. Whearease diabetes groups were significantly higher (p≤0.05) when compared with positive control except group which treated spearment 6% .