الفهرس 
Review of literatureOnly 14 pages are availabe for public view
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Abstract
Choroidal neovascularization (CNV) represents a pathologic growth of new
blood vessels extending from the choroid into the subretinal or subretinal pigment
epithelium space[1,2] . CNV results from a wide range of disorders that affect the RPE–
Bruch’s membrane–choriocapillaris complex. CNV may occur as a secondary
manifestation of various inherited and acquired conditions, including wet-type ARMD,
angioid streaks, high myopia, trauma, choroidal tumours and infectious and
inflammatory diseases. Idiopathic CNV refers to neovascularization which develops
from an unknown etiology[10,11] .FAF imaging is a non-invasive imaging method
which contributes to our understanding of the CNV pathophysiology and prognostic
markers for disease progression. The FAF signal is mainly derived from lipofuscin
accumulation at the RPE, but other retinal fluorophores that may occur in pathological
conditions such as fluid, hemorrhages, or melanin deposition must be differentiated.
This study include 30 patients have newly diagnosed choroidal
neovascularization. All patients examined at Menofia University outpatient clinic Each
patient was carefully informed about the purpose of the research and provided signed
consent. All patients underwent three consecutive monthly intravitreal anti-VEGF
injections, followed by as-needed injections. All patients underwent a complete
ophthalmologic examination, including an assessment of best-corrected visual acuity
(BCVA), slit lamp biomicroscopy, SD-OCT, FA and FAF imaging before the first
intravitreal anti-VEGF injection (pre-treatment)and after 6 months follow up period
following three monthly consecutive intravitreal anti-VEGF injections.
This work Study the different pathological autofluorescence patterns in
choroidal neovscularization before and after intra vitreal anti-VEGF injection.
The 30 eyes with newly diagnosed Choroidal neovascular membrane (CNVM)
showed 4 patterns, pattern I (Dot like small lobular well-defined fundus
autofluorescence defects within area of relative hypoautofluorescence surrounded by
hyperautofluorescence),pattern II (Focal area of relative hypoautofluorescence
surrounded by hyperautofluorescence),pattern III (Focal area of relative
hypoautofluorescence surrounded by isoautofluorescence), pattern IV (Large lobular or
multilobular well-defined fundus autofluorescence defects surrounded by
hyperautofluorescence). After 6 months follow up period following three intravitreal
anti-VEGF injections 10 eyes of pattern I, 7 eyes of pattern II and 7 eyes of pattern III
showed increase intensity of fundus autofluorescence. While one eye of pattern III and 5
eyes of pattern IV showed same intensity of fundus autofluorescence.