الفهرس 
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Abstract
The aim of this study was to evaluate the lamina cribrosa changes in patients with primary open angle glaucoma by swept-source optical coherence tomography.
This study included 20 eyes of healthy control subjects and 60 eyes with primary open angle glaucoma which further divided into three groups according to severity, mild, moderate and severe glaucoma groups; each group included 20 eyes.
All patients underwent full ophthalmic examination including: visual acuity assessment, anterior segment slit lamp examination, cycloplegic refraction, central corneal thickness measurement, fundus examination, axial length measurement, intraocular pressure measurement, visual field assessment.
Swept-Source optical coherence tomography was performed using 6-mm, 12-radial line scans centered on the optic disc. Bruch’s Membrane Opening distance was manually determined by measuring the distance between the Bruch’s membrane end-points of the optic nerve head. The distance between the reference line defining the BMO and the anterior reflectivity of the LC was measured perpendicular to the BMO line and defined as LC depth. The thickness of the LC was defined as the distance between the anterior and posterior borders of the highly reflective region. All the measurements were taken at the horizontal and the vertical scans and then the mean was taken.
The mean LC depth measured in the control group was 425.90 ± 106.34 µm, and 475.05 ± 67.18 µm, 523.94 ± 86.12 µm and 695.16 ± 109.88 µm in the mild, moderate and severe groups respectively. The mean LC thickness was 156.68 ± 22.23 µm while measured 141.79 ± 32.64 µm, 126.16 ± 21.45 µm, 115.76 ± 16.68 µm in the mild, moderate and severe glaucoma groups respectively.
The mean LC depth and thickness were of no statistical significance with the mild glaucoma group, while were statically significant with the moderate and the severe glaucoma groups.
Regarding the risk factors affecting LC depth, the mean LC depth measurements were statistically significant with the IOP, axial length, RNFL thickness and MD measurements of the patients, while LC depth was not statistically significant with the age nor the CCT of the patients.
In addition, for the risk factors affecting LC thickness, mean LC thickness measurements were statistically significant with IOP, axial length, RNFL thickness and MD measurements of the patients. However, they were of no statistical significance with neither the age nor CCT measurements of the patients.