الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Background: Diabetic retinopathy (DR) is a major complication of diabetes mellitus (DM), which remains a leading cause of visual loss in working-age populations. Aim of the Work: to evaluate relation between serum CTRP9 and diabetic retinopathy in patients with type 2 diabetes mellitus. Patients and Methods: In this cross sectional study, we collect 90 subjects with their ages ranging from 35-70, selected from diabetes and ophthalmology outpatient clinics of Ain shams University Hospitals for 6 months in a period from May 2019 to November 2019. They were divided into 3 groups: group (1): (35) Patients with T2DM with diabetic retinopathy. group (2): (35) Patients with T2DM without diabetic retinopathy. group (3): (20) Apparently healthy individuals. Results: there is highly statistical significant difference between the studied groups as regard S.CTRP9 being lowest in Group1 Patients with T2DM with diabetic retinopathy and much higher in group 2 Patients with T2DM without diabetic retinopathy and Group3 Apparently healthy individuals ,P value <0.001.Also we found negative correlation between serum CTRP9 level and Duration of DM, fasting blood sugar, 2hrs post prandial blood sugar, HbA1C. HbA1C was the most significant factor in comparison to S.CTRP9 (p value <0.001), Then Duration of DM was the second significant factor in comparison to S.CTRP9 (p value 0.029). Conclusion: Low level of S.CTRP9 in Group1 Patients with T2DM with diabetic retinopathy was found in our study .These findings could be explained by loss of protective role of CTRP9 in patients suffering from type 2DM with diabetic retinopathy and negative correlation between serum CTRP9 level and duration of DM (P-value <0.001) which seem to be exhaustion of this adipokine and worsening of insulin resistance. However more studied are needed to confirm this.